![]() I have read there is a connection (in ALS) between abnormal motor units (large amplitude) and the appearance of fasciculations- which means if there are ALS fasciculations – there will also be abnormal units – Is that true? And if not, how much time would it take for abnormal units to appear if there are already ALS fasciculations? (Weeks, months.)?įasciculations (at least Motor Neuron fascics) are a sign of ongoing reinnervation and can actually begin distally in regenerated nerve fibers. If the SNAP is abnormal consider a concomitant neuropathy of different etiology or revise your diagnosis to something other than ALS Abnormal motor units in ALS ![]() SNAPS or sensory nerve action potentials should be characteristically normal in ALS as the disease affects the anterior horn cell, (Amyotrophy) a motor neuron disease. While the compound muscle action potential (CMAP) is normal initially, but in advanced disease gets lower (even absent) due to severe loss of axons. ![]() The motor unit potential (MUP) gets higher in MND. ![]() What is the motor amplitude? Is it pathologically higher or lower than normal in ALS/MND? ![]()
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